By Charlotte Plestant, Louis Jeay, Suliman Bouizaguen, David Guet - 26 Jul 2021
Delivering the right treatment to the right patient, and at the right time. This motto has become the driving force in drug development, placing solutions empowering personalized medicine as a top priority in the Pathology field. The scientific community is striving to answer the technological needs required by such a challenge. Multiplex fluorescence IHC (immunohistochemistry) is a revolutionary method offering powerful possibilities in simultaneous analysis of multiple biomarkers on whole tissue sections. In this post, we describe why understanding spatial biology, the study of tissues in their 2D and 3D context, is the next big step the field has to take and how Deep Learning will assist in unraveling personalized medicine.
By Charlotte Plestant (Scientific Content Marketing Manager), Eunice Stennett (Former CMO), David Guet (Digital pathology Specialist) - 26 May 2021
Over the last years, the world of Pathology has considerably evolved and brought out new challenges. Development of whole-slide scanners alongside Artificial Intelligence (AI) has empowered pathological analysis by digitizing immunohistochemistry, immunocytochemistry and H&E slides, providing better possibilities in patient selection and treatment. These changes have come with new hurdles, related to a sharp increase of the complexity of the images, higher expectations for image analysis and a shift in the pathologist's daily practices.
By Sylvain Berlemont (CEO), Shazia Osman (Senior BD), Kevin Adam (Senior BD) - 02 Apr 2021
Keen Eye is attending the Biomarker Series Week starting May 17th to the 21st! Our CEO, Sylvain Berlemont will introduce Keen Eye in a Thought Leader presentation and our business team will be happy to meet you to discuss about your biomarker research and analysis projects.
By David Guet (Digital Pathology Specialist), Melanie Lubrano (Data Scientist) - 30 Mar 2021
Histopathology is the analysis of tissue samples under a microscope in order to establish the severity of a disease. More precisely, it concerns the examination of tissue extracted from surgery, biopsy or autopsy. The tissue extracted from the body of the patient is placed in a fixative medium in order to prevent decay. It is then embedded in a cassette in wax before being sliced in thin microtome sections. Thin tissue sections are stained using different staining protocols (H&E, chromogenic, immunofluorescence, etc.) and mounted on glass slides before observation.
08 Mar 2021
Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is a condition characterized by the repeated growth of benign exophytic papilloma in the respiratory tract. The course of the disease remains unpredictable: some children experience minor symptoms, while others require multiple interventions due to florid growth. Our study aimed to identify histologic severity risk factors in patients with JoRRP. Forty-eight children from two French pediatric centers were included retrospectively.
By Eunice Stennett, David Guet, Hippolyte Heuberger - 02 Mar 2021
Data science is the art of extracting and interpreting relevant information from large amounts of complex data. It has evolved rapidly over the years and is now recognized as a valuable medical image analysis tool. Until recently, the field of computational pathology relied on machine learning (ML) methods. These are highly-supervised algorithms designed to learn human-crafted annotations, and extract and decipher relevant features from their analysis. Keen Eye image-based biomarker analysis, on the other hand, relies on deep-learning (DL) methods. Those semi-supervised or unsupervised algorithms improve feature extraction and interpretability from translational to clinical research.